Riccardo Fodde’s Publications

Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell. 2016 Jul 7;19(1):38-51. doi: 10.1016/j.stem.2016.05.023. Epub 2016 Jun 9. PubMed PMID: 27292189.
Famili F, Brugman MH, Taskesen E, Naber BE, Fodde R, Staal FJ. High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells. Stem Cell Reports. 2016 May 10;6(5):652-9. doi: 10.1016/j.stemcr.2016.04.009. PubMed PMID: 27167156; PubMed Central PMCID: PMC4939829. PDF
Cremers N, Neeb A, Uhle T, Dimmler A, Rothley M, Allgayer H, Fodde R, Sleeman JP, Thiele W. CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models. PLoS One. 2016 Mar 15;11(3):e0151468. doi: 10.1371/journal.pone.0151468. eCollection 2016. PubMed PMID: 26978528; PubMed Central PMCID: PMC4792398. PDF
Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Møller P, Viel A, Genuardi M, Fodde R, Bellacosa A. Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. Oncotarget. 2015 Dec 15;6(40):42892-904. doi: 10.18632/oncotarget.5740. PubMed PMID: 26503472; PubMed Central PMCID: PMC4767479. PDF
van der Zee M, Sacchetti A, Cansoy M, Joosten R, Teeuwssen M, Heijmans-Antonissen C, Ewing-Graham PC, Burger CW, Blok LJ, Fodde R. IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+Stem-like Component and Reduces Tumor Burden. Cancer Res. 2015 Sep 1;75(17):3608-22. doi: 10.1158/0008-5472.CAN-14-2498. Epub 2015 Jun 30. PubMed PMID: 26130650. PDF
Ling H, Vincent K, Pichler M, Fodde R, Berindan-Neagoe I, Slack FJ, Calin GA. Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 2015 Sep 24;34(39):5003-11. doi: 10.1038/onc.2014.456. Epub 2015 Jan 26. Review. PubMed PMID: 25619839; PubMed Central PMCID: PMC4552604.
Reimers MS, Bastiaannet E, Langley RE, van Eijk R, van Vlierberghe RL, Lemmens VE, van Herk-Sukel MP, van Wezel T, Fodde R, Kuppen PJ, Morreau H, van de Velde CJ, Liefers GJ. Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer. JAMA Intern Med. 2014 May;174(5):732-9. doi: 10.1001/jamainternmed.2014.511. PubMed PMID: 24687028.
Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T. Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia. Mol Brain. 2014 Mar 29;7:21. doi: 10.1186/1756-6606-7-21. PubMed PMID: 24678719; PubMed Central PMCID: PMC3986642. PDF
Atlasi Y, Looijenga L, Fodde R. Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective. Curr Top Dev Biol. 2014;107:373-404. doi: 10.1016/B978-0-12-416022-4.00013-5. Review. PubMed PMID: 24439813.
Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, Zhang X, de Weerd V, Shimizu M, Ling H, Buiga R, Pop V, Irimie A, Fodde R, Bedrosian I, Martens JW, Foekens JA, Berindan-Neagoe I, Calin GA. CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget. 2013 Oct;4(10):1748-62. PubMed PMID: 24077681; PubMed Central PMCID: PMC3858561. PDF
Ghazvini M, Sonneveld P, Kremer A, Franken P, Sacchetti A, Atlasi Y, Roth S, Joosten R, Smits R, Fodde R. Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis. PLoS One. 2013 Sep 17;8(9):e73872. doi: 10.1371/journal.pone.0073872. eCollection 2013. PubMed PMID: 24069241; PubMed Central PMCID: PMC3775784. PDF
Monteiro J, Gaspar C, Richer W, Franken PF, Sacchetti A, Joosten R, Idali A, Brandao J, Decraene C, Fodde R. Cancer stemness in Wnt-driven mammary tumorigenesis. Carcinogenesis. 2014 Jan;35(1):2-13. doi: 10.1093/carcin/bgt279. Epub 2013 Aug 16. PubMed PMID: 23955540. PDF
Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep;23(9):1446-61. doi: 10.1101/gr.152942.112. Epub 2013 Jun 24. PubMed PMID: 23796952; PubMed Central PMCID: PMC3759721. PDF
Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R. Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation. PLoS Genet. 2013 May;9(5):e1003424. doi: 10.1371/journal.pgen.1003424. Epub 2013 May 2. PubMed PMID: 23658527; PubMed Central PMCID: PMC3642041. PDF
van der Zee M, Jia Y, Wang Y, Heijmans-Antonissen C, Ewing PC, Franken P, DeMayo FJ, Lydon JP, Burger CW, Fodde R, Blok LJ. Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J Pathol. 2013 May;230(1):48-58. doi: 10.1002/path.4160. Epub 2013 Mar 14. PubMed PMID: 23288720. PDF
Mathers JC, Movahedi M, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans G, Maher ER, Bertario L, Bisgaard ML, Dunlop M, Ho JW, Hodgson S, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen H, Gerdes AM, Barker G, Crawford G, Elliott F, Pylvanainen K, Wijnen J, Fodde R, Lynch H, Bishop DT, Burn J; CAPP2 Investigators. Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol. 2012 Dec;13(12):1242-9. doi: 10.1016/S1470-2045(12)70475-8. Epub 2012 Nov 7. PubMed PMID: 23140761.
Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Fodde R, Itoh M, Senda T. Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc. Med Mol Morphol. 2012 Jun;45(3):161-7. Epub 2012 Sep 22. PubMed PMID: 23001298.
Wang Y, Sacchetti A, van Dijk MR, van der Zee M, van der Horst PH, Joosten R, Burger CW, Grootegoed JA, Blok LJ, Fodde R. Identification of quiescent, stem-like cells in the distal female reproductive tract. PLoS One. 2012;7(7):e40691. doi: 10.1371/journal.pone.0040691. Epub 2012 Jul 24. PubMed PMID: 22848396; PubMed Central PMCID: PMC3404087.
Sampieri K, Fodde R. Cancer stem cells and metastasis. Semin Cancer Biol. 2012 Jun;22(3):187-93. Review. PubMed PMID: 22774232.
Roth S, Franken P, Sacchetti A, Kremer A, Anderson K, Sansom O, Fodde R. Paneth cells in intestinal homeostasis and tissue injury. PLoS One. 2012;7(6):e38965. doi: 10.1371/journal.pone.0038965. Epub 2012 Jun 20. PubMed PMID: 22745693; PubMed Central PMCID: PMC3380033.
Roth S, Franken P, Monkhorst K, Kong a San J, Fodde R. Generation and characterization of an inducible transgenic model for studying mouse esophageal biology. BMC Dev Biol. 2012 Jun 12;12:18. doi: 10.1186/1471-213X-12-18. PubMed PMID: 22690876; PubMed Central PMCID: PMC3483200.
Bastiaannet E, Sampieri K, Dekkers OM, de Craen AJ, van Herk-Sukel MP, Lemmens V, van den Broek CB, Coebergh JW, Herings RM, van de Velde CJ, Fodde R, Liefers GJ. Use of aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer. 2012 Apr 24;106(9):1564-70. doi: 10.1038/bjc.2012.101. Epub 2012 Mar 27. PubMed PMID: 22454078; PubMed Central PMCID: PMC3341868.
Sleeman JP, Christofori G, Fodde R, Collard JG, Berx G, Decraene C, Rüegg C. Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol. 2012 Jun;22(3):174-86. doi: 10.1016/j.semcancer.2012.02.007. Epub 2012 Feb 21. Review. PubMed PMID: 22374376.
Fijneman RJ, de Wit M, Pourghiasian M, Piersma SR, Pham TV, Warmoes MO, Lavaei M, Piso C, Smit F, Delis-van Diemen PM, van Turenhout ST, Terhaar sive Droste JS, Mulder CJ, Blankenstein MA, Robanus-Maandag EC, Smits R, Fodde R, van Hinsbergh VW, Meijer GA, Jimenez CR. Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer. Clin Cancer Res. 2012 May 1;18(9):2613-24. doi: 10.1158/1078-0432.CCR-11-1937. Epub 2012 Feb 20. PubMed PMID: 22351690.
Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Oda N, Fodde R, Itoh M, Senda T. The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function. Med Mol Morphol. 2011 Dec;44(4):207-12. doi: 10.1007/s00795-010-0529-9. Epub 2011 Dec 17. PubMed PMID: 22179183.
Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans DG, Maher ER, Bertario L, Bisgaard ML, Dunlop MG, Ho JW, Hodgson SV, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen HF, Barker G, Crawford G, Elliott F, Movahedi M, Pylvanainen K, Wijnen JT, Fodde R, Lynch HT, Mathers JC, Bishop DT; CAPP2 Investigators. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet. 2011 Dec 17;378(9809):2081-7. doi: 10.1016/S0140-6736(11)61049-0. Epub 2011 Oct 27. PubMed PMID: 22036019; PubMed Central PMCID: PMC3243929.
Luis TC, Naber BA, Roozen PP, Brugman MH, de Haas EF, Ghazvini M, Fibbe WE, van Dongen JJ, Fodde R, Staal FJ. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell. 2011 Oct 4;9(4):345-56. doi: 10.1016/j.stem.2011.07.017. PubMed PMID: 21982234.
Robanus-Maandag E, Bosch C, Amini-Nik S, Knijnenburg J, Szuhai K, Cervera P, Poon R, Eccles D, Radice P, Giovannini M, Alman BA, Tejpar S, Devilee P, Fodde R. Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids. PLoS One. 2011;6(9):e24354. doi: 10.1371/journal.pone.0024354. Epub 2011 Sep 9. PubMed PMID: 21931686; PubMed Central PMCID: PMC3170296.
Roth S, Fodde R. Quiescent stem cells in intestinal homeostasis and cancer. Cell Commun Adhes. 2011 Jun;18(3):33-44. doi: 10.3109/15419061.2011.615422. Epub 2011 Sep 14. PubMed PMID: 21913875.
Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schüller U. Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors. Mol Cell Biol. 2011 Aug;31(16):3326-38. doi: 10.1128/MCB.05718-11. Epub 2011 Jun 20. PubMed PMID: 21690300; PubMed Central PMCID: PMC3147790.
Wang Y, Jia Y, Franken P, Smits R, Ewing PC, Lydon JP, DeMayo FJ, Burger CW, Anton Grootegoed J, Fodde R, Blok LJ. Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):48-54. doi: 10.1016/j.mce.2011.05.026. Epub 2011 Jun 1. PubMed PMID: 21664244.
Roth S, Fodde R. The nature of intestinal stem cells’ nurture. EMBO Rep. 2011 Jun;12(6):483-4. doi: 10.1038/embor.2011.97. Epub 2011 May 13. PubMed PMID: 21566649; PubMed Central PMCID: PMC3128296.
Burn J, Bishop DT, Chapman PD, Elliott F, Bertario L, Dunlop MG, Eccles D, Ellis A, Evans DG, Fodde R, Maher ER, Möslein G, Vasen HF, Coaker J, Phillips RK, Bülow S, Mathers JC; International CAPP consortium. A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. Cancer Prev Res (Phila). 2011 May;4(5):655-65. doi: 10.1158/1940-6207.CAPR-11-0106. PubMed PMID: 21543343; PubMed Central PMCID: PMC3092423.
Wang Y, van der Zee M, Fodde R, Blok LJ. Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer. Oncotarget. 2010 Nov;1(7):674-84. Review. PubMed PMID: 21317462; PubMed Central PMCID: PMC3248134.
van Veelen W, Le NH, Helvensteijn W, Blonden L, Theeuwes M, Bakker ER, Franken PF, van Gurp L, Meijlink F, van der Valk MA, Kuipers EJ, Fodde R, Smits R. β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis. Gut. 2011 Sep;60(9):1204-12. doi: 10.1136/gut.2010.233460. Epub 2011 Feb 9. PubMed PMID: 21307168; PubMed Central PMCID: PMC3152867.
Grotenhuis BA, Franken PF, Swinkels WJ, Boonstra A, van der Valk MA, van Lanschot JJ, Fodde R. Early morbidity encountered in the dietary-related mouse model of Barrett’s esophagus: a question of zinc? Dis Esophagus. 2011 Jul;24(5):371-3. doi: 10.1111/j.1442-2050.2010.01151.x. Epub 2010 Dec 17. PubMed PMID: 21166735.
Meunier D, Patra K, Smits R, Hägebarth A, Lüttges A, Jaussi R, Wieduwilt MJ, Quintanilla-Fend L, Himmelbauer H, Fodde R, Fundele RH. Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. Mol Carcinog. 2011 Jan;50(1):8-15. doi: 10.1002/mc.20692. PubMed PMID: 21061267.
Out AA, Tops CM, Nielsen M, Weiss MM, van Minderhout IJ, Fokkema IF, Buisine MP, Claes K, Colas C, Fodde R, Fostira F, Franken PF, Gaustadnes M, Heinimann K, Hodgson SV, Hogervorst FB, Holinski-Feder E, Lagerstedt-Robinson K, Olschwang S, van den Ouweland AM, Redeker EJ, Scott RJ, Vankeirsbilck B, Grønlund RV, Wijnen JT, Wikman FP, Aretz S, Sampson JR, Devilee P, den Dunnen JT, Hes FJ. Leiden Open Variation Database of the MUTYH gene. Hum Mutat. 2010 Nov;31(11):1205-15. doi: 10.1002/humu.21343. PubMed PMID: 20725929.
Grotenhuis BA, Dinjens WN, Wijnhoven BP, Sonneveld P, Sacchetti A, Franken PF, van Dekken H, Tilanus HW, van Lanschot JJ, Fodde R. Barrett’s oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers. J Pathol. 2010 Aug;221(4):379-89. doi: 10.1002/path.2733. PubMed PMID: 20549647.
Albuquerque C, Baltazar C, Filipe B, Penha F, Pereira T, Smits R, Cravo M, Lage P, Fidalgo P, Claro I, Rodrigues P, Veiga I, Ramos JS, Fonseca I, Leitão CN, Fodde R. Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. Genes Chromosomes Cancer. 2010 Aug;49(8):746-59. doi: 10.1002/gcc.20786. PubMed PMID: 20544848.
Fodde R, Tomlinson I. Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma. J Pathol. 2010 Jul;221(3):239-41. doi: 10.1002/path.2718. PubMed PMID: 20527017.
Monteiro J, Fodde R. Cancer stemness and metastasis: therapeutic consequences and perspectives. Eur J Cancer. 2010 May;46(7):1198-203. doi: 10.1016/j.ejca.2010.02.030. Epub 2010 Mar 18. Review. PubMed PMID: 20303259.
Robanus-Maandag EC, Koelink PJ, Breukel C, Salvatori DC, Jagmohan-Changur SC, Bosch CA, Verspaget HW, Devilee P, Fodde R, Smits R. A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis. 2010 May;31(5):946-52. doi: 10.1093/carcin/bgq046. Epub 2010 Feb 22. PubMed PMID: 20176656.
Wang Y, Hanifi-Moghaddam P, Hanekamp EE, Kloosterboer HJ, Franken P, Veldscholte J, van Doorn HC, Ewing PC, Kim JJ, Grootegoed JA, Burger CW, Fodde R, Blok LJ. Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer. Clin Cancer Res. 2009 Sep 15;15(18):5784-93. doi: 10.1158/1078-0432.CCR-09-0814. Epub 2009 Sep 8. PubMed PMID: 19737954.
Gaspar C, Franken P, Molenaar L, Breukel C, van der Valk M, Smits R, Fodde R. A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet. 2009 Jul;5(7):e1000547. doi: 10.1371/journal.pgen.1000547. Epub 2009 Jul 3. PubMed PMID: 19578404; PubMed Central PMCID: PMC2697381.
Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC. Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009 Apr 8;9:26. doi: 10.1186/1471-213X-9-26. PubMed PMID: 19356224; PubMed Central PMCID: PMC2678105.
Fodde R. The stem of cancer. Cancer Cell. 2009 Feb 3;15(2):87-9. doi: 10.1016/j.ccr.2009.01.011. PubMed PMID: 19185843.
Burn J, Bishop DT, Mecklin JP, Macrae F, Möslein G, Olschwang S, Bisgaard ML, Ramesar R, Eccles D, Maher ER, Bertario L, Jarvinen HJ, Lindblom A, Evans DG, Lubinski J, Morrison PJ, Ho JW, Vasen HF, Side L, Thomas HJ, Scott RJ, Dunlop M, Barker G, Elliott F, Jass JR, Fodde R, Lynch HT, Mathers JC; CAPP2 Investigators. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med. 2008 Dec 11;359(24):2567-78. doi: 10.1056/NEJMoa0801297. Erratum in: N Engl J Med. 2009 Apr 2;360(14):1470. PubMed PMID: 19073976.
Alberici P, Gaspar C, Franken P, Gorski MM, de Vries I, Scott RJ, Ristimäki A, Aaltonen LA, Fodde R. Smad4 haploinsufficiency: a matter of dosage. Pathogenetics. 2008 Nov 3;1(1):2. doi: 10.1186/1755-8417-1-2. PubMed PMID: 19014666; PubMed Central PMCID: PMC2580039.
Roth S, Franken P, van Veelen W, Blonden L, Raghoebir L, Beverloo B, van Drunen E, Kuipers EJ, Rottier R, Fodde R, Smits R. Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology. Genesis. 2009 Jan;47(1):7-13. doi: 10.1002/dvg.20446. PubMed PMID: 18942097.
Alberici P, Fodde R. The role of the APC tumor suppressor in chromosomal instability. Genome Dyn. 2006;1:149-70. doi: 10.1159/000092506. Review. PubMed PMID: 18724059.
Liljegren A, Barker G, Elliott F, Bertario L, Bisgaard ML, Eccles D, Evans G, Macrae F, Maher E, Lindblom A, Rotstein S, Nilsson B, Mecklin JP, Möslein G, Jass J, Fodde R, Mathers J, Burn J, Bishop DT. Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol. 2008 Jul 10;26(20):3434-9. doi: 10.1200/JCO.2007.13.2795. PubMed PMID: 18612159; PubMed Central PMCID: PMC2645083.
Le NH, Franken P, Fodde R. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br J Cancer. 2008 Jun 17;98(12):1886-93. doi: 10.1038/sj.bjc.6604401. Epub 2008 May 27. Review. PubMed PMID: 18506144; PubMed Central PMCID: PMC2441948.
Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J. cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7281-6. doi: 10.1073/pnas.0711190105. Epub 2008 May 19. PubMed PMID: 18490653; PubMed Central PMCID: PMC2387183.
Gaspar C, Cardoso J, Franken P, Molenaar L, Morreau H, Möslein G, Sampson J, Boer JM, de Menezes RX, Fodde R. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol. 2008 May;172(5):1363-80. doi: 10.2353/ajpath.2008.070851. Epub 2008 Apr 10. PubMed PMID: 18403596; PubMed Central PMCID: PMC2329845.
Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-66. Epub 2007 Jun 14. PubMed PMID: 17569777; PubMed Central PMCID: PMC1934515.
van Dekken H, Wink JC, Vissers KJ, Franken PF, Ruud Schouten W, J Hop WC, Kuipers EJ, Fodde R, Janneke van der Woude C. Wnt pathway-related gene expression during malignant progression in ulcerative colitis. Acta Histochem. 2007;109(4):266-72. Epub 2007 Apr 18. PubMed PMID: 17445872.
Fodde R, Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol. 2007 Apr;19(2):150-8. Epub 2007 Feb 16. Review. PubMed PMID: 17306971.
Alberici P, de Pater E, Cardoso J, Bevelander M, Molenaar L, Jonkers J, Fodde R. Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am J Pathol. 2007 Jan;170(1):377-87. PubMed PMID: 17200209; PubMed Central PMCID: PMC1762685.
Fodde R. Stem cells and metastatic cancer: fatal attraction? PLoS Med. 2006 Dec;3(12):e482. PubMed PMID: 17194186; PubMed Central PMCID: PMC1762040.
Drabek K, van Ham M, Stepanova T, Draegestein K, van Horssen R, Sayas CL, Akhmanova A, Ten Hagen T, Smits R, Fodde R, Grosveld F, Galjart N. Role of CLASP2 in microtubule stabilization and the regulation of persistent motility. Curr Biol. 2006 Nov 21;16(22):2259-64. PubMed PMID: 17113391.
Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, Rosty C, Abal M, El Marjou F, Smits R, Louvard D, Fodde R, Robine S. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology. 2006 Oct;131(4):1096-109. Epub 2006 Aug 16. Erratum in: Gastroenterology. 2006 Dec;131(6):2029. PubMed PMID: 17030180.
Cardoso J, Boer J, Morreau H, Fodde R. Expression and genomic profiling of colorectal cancer. Biochim Biophys Acta. 2007 Jan;1775(1):103-37. Epub 2006 Aug 22. Review. PubMed PMID: 17010523.
Sakai H, Visser R, Ikegawa S, Ito E, Numabe H, Watanabe Y, Mikami H, Kondoh T, Kitoh H, Sugiyama R, Okamoto N, Ogata T, Fodde R, Mizuno S, Takamura K, Egashira M, Sasaki N, Watanabe S, Nishimaki S, Takada F, Nagai T, Okada Y, Aoka Y, Yasuda K, Iwasa M, Kogaki S, Harada N, Mizuguchi T, Matsumoto N. Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes. Am J Med Genet A. 2006 Aug 15;140(16):1719-25. PubMed PMID: 16835936.
Cardoso J, Molenaar L, de Menezes RX, van Leerdam M, Rosenberg C, Möslein G, Sampson J, Morreau H, Boer JM, Fodde R. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res. 2006 Mar 1;66(5):2514-9. PubMed PMID: 16510566.
Lynch HT, Boland CR, Gong G, Shaw TG, Lynch PM, Fodde R, Lynch JF, de la Chapelle A. Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet. 2006 Apr;14(4):390-402. Review. PubMed PMID: 16479259.
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Nagtegaal ID, Gaspar CG, Peltenburg LT, Marijnen CA, Kapiteijn E, van de Velde CJ, Fodde R, van Krieken JH. Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma. Virchows Arch. 2005 Feb;446(2):127-35. Epub 2004 Dec 16. PubMed PMID: 15602683.
Cardoso J, Molenaar L, de Menezes RX, Rosenberg C, Morreau H, Möslein G, Fodde R, Boer JM. Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH. Nucleic Acids Res. 2004 Oct 28;32(19):e146. PubMed PMID: 15514107; PubMed Central PMCID: PMC528818.
Nagtegaal I, Gaspar C, Marijnen C, Van De Velde C, Fodde R, Van Krieken H. Morphological changes in tumour type after radiotherapy are accompanied by changes in gene expression profile but not in clinical behaviour. J Pathol. 2004 Oct;204(2):183-92. PubMed PMID: 15378567.
Gaspar C, Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol. 2004;48(5-6):377-86. Review. PubMed PMID: 15349813.
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Hendriks YM, Wagner A, Morreau H, Menko F, Stormorken A, Quehenberger F, Sandkuijl L, Møller P, Genuardi M, Van Houwelingen H, Tops C, Van Puijenbroek M, Verkuijlen P, Kenter G, Van Mil A, Meijers-Heijboer H, Tan GB, Breuning MH, Fodde R, Wijnen JT, Bröcker-Vriends AH, Vasen H. Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance. Gastroenterology. 2004 Jul;127(1):17-25. PubMed PMID: 15236168.
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Stormorken AT, Müller W, Lemkemeyer B, Apold J, Wijnen JT, Fodde R, Möslein G, Møller P. Prediction of the outcome of genetic testing in HNPCC kindreds using the revised Amsterdam criteria and immunohistochemistry. Fam Cancer. 2001;1(3-4):169-73. PubMed PMID: 14574174.
Tolg C, Poon R, Fodde R, Turley EA, Alman BA. Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene. 2003 Oct 9;22(44):6873-82. PubMed PMID: 14534534.
Bezrookove V, Smits R, Moeslein G, Fodde R, Tanke HJ, Raap AK, Darroudi F. Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers. Genes Chromosomes Cancer. 2003 Oct;38(2):177-86. PubMed PMID: 12939745.
Watson P, Narod SA, Fodde R, Wagner A, Lynch JF, Tinley ST, Snyder CL, Coronel SA, Riley B, Kinarsky Y, Lynch HT. Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. J Med Genet. 2003 Aug;40(8):591-6. PubMed PMID: 12920070; PubMed Central PMCID: PMC1735553.
Hohenstein P, Fodde R. Of mice and (wo)men: genotype-phenotype correlations in BRCA1. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R271-7. Epub 2003 Aug 5. Review. Erratum in: Hum Mol Genet. 2004 Feb 15;13(4):473. PubMed PMID: 12915453.
Soravia C, van der Klift H, Bründler MA, Blouin JL, Wijnen J, Hutter P, Fodde R, Delozier-Blanchet C. Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. Am J Med Genet A. 2003 Aug 30;121A(2):159-62. PubMed PMID: 12910497.
Vrolijk H, Sloos W, Mesker W, Franken P, Fodde R, Morreau H, Tanke H. Automated acquisition of stained tissue microarrays for high-throughput evaluation of molecular targets. J Mol Diagn. 2003 Aug;5(3):160-7. PubMed PMID: 12876206; PubMed Central PMCID: PMC1907332.
Scheenstra R, Rijcken FE, Koornstra JJ, Hollema H, Fodde R, Menko FH, Sijmons RH, Bijleveld CM, Kleibeuker JH. Rapidly progressive adenomatous polyposis in a patient with germline mutations in both the APC and MLH1 genes: the worst of two worlds. Gut. 2003 Jun;52(6):898-9. PubMed PMID: 12740349; PubMed Central PMCID: PMC1773670.
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Fodde R. The multiple functions of tumour suppressors: it’s all in APC. Nat Cell Biol. 2003 Mar;5(3):190-2. PubMed PMID: 12646874.
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Kielman MF, Rindapää M, Gaspar C, van Poppel N, Breukel C, van Leeuwen S, Taketo MM, Roberts S, Smits R, Fodde R. Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet. 2002 Dec;32(4):594-605. Epub 2002 Nov 11. Erratum in: Nat Genet. 2003 Jan;33(1):107.. PubMed PMID: 12426568.
Fodde R, Smits R. Cancer biology. A matter of dosage. Science. 2002 Oct 25;298(5594):761-3. PubMed PMID: 12399571.
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Ridanpää M, Fodde R, Kielman M. Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. Mech Dev. 2001 Dec;109(2):173-81. PubMed PMID: 11731231.
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Fodde R, Smits R. Disease model: familial adenomatous polyposis. Trends Mol Med. 2001 Aug;7(8):369-73. Review. PubMed PMID: 11516998.
Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R. A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50. PubMed PMID: 11420664.
Wagner A, Hendriks Y, Meijers-Heijboer EJ, de Leeuw WJ, Morreau H, Hofstra R, Tops C, Bik E, Bröcker-Vriends AH, van Der Meer C, Lindhout D, Vasen HF, Breuning MH, Cornelisse CJ, van Krimpen C, Niermeijer MF, Zwinderman AH, Wijnen J, Fodde R. Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree. J Med Genet. 2001 May;38(5):318-22. PubMed PMID: 11333868; PubMed Central PMCID: PMC1734864.
Poon R, Smits R, Li C, Jagmohan-Changur S, Kong M, Cheon S, Yu C, Fodde R, Alman BA. Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). Oncogene. 2001 Jan 25;20(4):451-60. PubMed PMID: 11313976.
Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, Clevers H. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol. 2001 Apr;3(4):433-8. PubMed PMID: 11283620.
Peelen T, de Leeuw W, van Lent K, Morreau H, van Eijk R, van Vliet M, Wijnen J, Ligtenberg M, Ginjaar HB, Zweemer R, Menko F, Fodde R, van Ommen GJ, Vasen HF, Cornelisse CJ, Devilee P. Genetic analysis of a breast-ovarian cancer family, with 7 cases of colorectal cancer linked to BRCA1, fails to support a role for BRCA1 in colorectal tumorigenesis. Int J Cancer. 2000 Dec 1;88(5):778-82. PubMed PMID: 11072248.
Sijmons R, Hofstra R, Hollema H, Mensink R, van der Hout A, Hoekstra H, Kleibeuker J, Molenaar W, Wijnen J, Fodde R, Vasen H, Buys C. Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer. Genes Chromosomes Cancer. 2000 Dec;29(4):353-5. PubMed PMID: 11066081.
Bouffler SD, Hofland N, Cox R, Fodde R. Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis. Br J Cancer. 2000 Nov;83(10):1291-4. PubMed PMID: 11044352; PubMed Central PMCID: PMC2408782.
Smits R, Ruiz P, Diaz-Cano S, Luz A, Jagmohan-Changur S, Breukel C, Birchmeier C, Birchmeier W, Fodde R. E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology. 2000 Oct;119(4):1045-53. PubMed PMID: 11040191.
Smits R, Hofland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R. Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosomes Cancer. 2000 Nov;29(3):229-39. PubMed PMID: 10992298.
Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B. A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. Clin Genet. 2000 Mar;57(3):205-12. PubMed PMID: 10782927.
Fidalgo P, Almeida MR, West S, Gaspar C, Maia L, Wijnen J, Albuquerque C, Curtis A, Cravo M, Fodde R, Leitao CN, Burn J. Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach. Eur J Hum Genet. 2000 Jan;8(1):49-53. PubMed PMID: 10713887.
Fodde R, Smits R, Hofland N, Kielman M, Meera Khan P. Mechanisms of APC-driven tumorigenesis: lessons from mouse models. Cytogenet Cell Genet. 1999;86(2):105-11. Review. PubMed PMID: 10545699.
Wijnen J, de Leeuw W, Vasen H, van der Klift H, Møller P, Stormorken A, Meijers-Heijboer H, Lindhout D, Menko F, Vossen S, Möslein G, Tops C, Bröcker-Vriends A, Wu Y, Hofstra R, Sijmons R, Cornelisse C, Morreau H, Fodde R. Familial endometrial cancer in female carriers of MSH6 germline mutations. Nat Genet. 1999 Oct;23(2):142-4. PubMed PMID: 10508506.
van der Houven van Oordt CW, Smits R, Schouten TG, Houwing-Duistermaat JJ, Williamson SL, Luz A, Meera Khan P, van der Eb AJ, Breuer ML, Fodde R. The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model. Genes Chromosomes Cancer. 1999 Mar;24(3):191-8. PubMed PMID: 10451698.
Calin G, Wijnen J, van der Klift H, Ionita A, Mulder A, Breukel C, Smits R, Dauwerse H, Hansson K, Calin S, Stefanescu D, Oproiu A, Fodde R. Marfan-like habitus and familial adenomatous polyposis in two unrelated males: a significant association? Eur J Hum Genet. 1999 Jul;7(5):609-14. PubMed PMID: 10439970.
Menko FH, Griffioen G, Wijnen JT, Tops CM, Fodde R, Vasen HF. [Genetics of colorectal cancer. II. Hereditary background of sporadic and familial colorectal cancer]. Ned Tijdschr Geneeskd. 1999 Jun 5;143(23):1207-11. Review. Dutch. PubMed PMID: 10389535.
Menko FH, Griffioen G, Wijnen JT, Tops CM, Fodde R, Vasen HF. [Genetics of colorectal cancer. I. Non-polyposis and polyposis forms of hereditary colorectal cancer]. Ned Tijdschr Geneeskd. 1999 Jun 5;143(23):1201-6. Review. Dutch. PubMed PMID: 10389534.
Smits R, Kielman MF, Breukel C, Zurcher C, Neufeld K, Jagmohan-Changur S, Hofland N, van Dijk J, White R, Edelmann W, Kucherlapati R, Khan PM, Fodde R. Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development. Genes Dev. 1999 May 15;13(10):1309-21. PubMed PMID: 10346819; PubMed Central PMCID: PMC316713.
Williamson SL, Kartheuser A, Coaker J, Kooshkghazi MD, Fodde R, Burn J, Mathers JC. Intestinal tumorigenesis in the Apc1638N mouse treated with aspirin and resistant starch for up to 5 months. Carcinogenesis. 1999 May;20(5):805-10. PubMed PMID: 10334197.
Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, Clevers H, Pals ST. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol. 1999 Feb;154(2):515-23. PubMed PMID: 10027409; PubMed Central PMCID: PMC1850011.
Kartheuser A, Walon C, West S, Breukel C, Detry R, Gribomont AC, Hamzehloei T, Hoang P, Maiter D, Pringot J, Rahier J, Khan PM, Curtis A, Burn J, Fodde R, Verellen-Dumoulin C. Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3′ APC mutation. J Med Genet. 1999 Jan;36(1):65-7. PubMed PMID: 9950370; PubMed Central PMCID: PMC1762946.
Wijnen J, van der Klift H, Vasen H, Khan PM, Menko F, Tops C, Meijers Heijboer H, Lindhout D, Møller P, Fodde R. MSH2 genomic deletions are a frequent cause of HNPCC. Nat Genet. 1998 Dec;20(4):326-8. PubMed PMID: 9843200.
Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S. A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998 Nov 15;58(22):5248-57. Review. PubMed PMID: 9823339.
Wijnen JT, Vasen HF, Khan PM, Zwinderman AH, van der Klift H, Mulder A, Tops C, Møller P, Fodde R. Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. N Engl J Med. 1998 Aug 20;339(8):511-8. PubMed PMID: 9709044.
Smits R, van der Houven van Oordt W, Luz A, Zurcher C, Jagmohan-Changur S, Breukel C, Khan PM, Fodde R. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology. 1998 Feb;114(2):275-83. PubMed PMID: 9453487.
van der Houven van Oordt CW, Smits R, Williamson SL, Luz A, Khan PM, Fodde R, van der Eb AJ, Breuer ML. Intestinal and extra-intestinal tumor multiplicities in the Apc1638N mouse model after exposure to X-rays. Carcinogenesis. 1997 Nov;18(11):2197-203. PubMed PMID: 9395221.
Wijnen J, Khan PM, Vasen H, van der Klift H, Mulder A, van Leeuwen-Cornelisse I, Bakker B, Losekoot M, Møller P, Fodde R. Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations. Am J Hum Genet. 1997 Aug;61(2):329-35. PubMed PMID: 9311737; PubMed Central PMCID: PMC1715907.
Sørensen IK, Kristiansen E, Mortensen A, van Kranen H, van Kreijl C, Fodde R, Thorgeirsson SS. Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice. Carcinogenesis. 1997 Apr;18(4):777-81. PubMed PMID: 9111214.
Harteveld KL, Losekoot M, Fodde R, Giordano PC, Bernini LF. The involvement of Alu repeats in recombination events at the alpha-globin gene cluster: characterization of two alphazero-thalassaemia deletion breakpoints. Hum Genet. 1997 Apr;99(4):528-34. PubMed PMID: 9099846.
Yang K, Edelmann W, Fan K, Lau K, Kolli VR, Fodde R, Khan PM, Kucherlapati R, Lipkin M. A mouse model of human familial adenomatous polyposis. J Exp Zool. 1997 Feb 15;277(3):245-54. PubMed PMID: 9062998.
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van der Luijt RB, Khan PM, Vasen HF, Tops CM, van Leeuwen-Cornelisse IS, Wijnen JT, van der Klift HM, Plug RJ, Griffioen G, Fodde R. Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis. Hum Mutat. 1997;9(1):7-16. PubMed PMID: 8990002.
Eccles DM, van der Luijt R, Breukel C, Bullman H, Bunyan D, Fisher A, Barber J, du Boulay C, Primrose J, Burn J, Fodde R. Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene. Am J Hum Genet. 1996 Dec;59(6):1193-201. PubMed PMID: 8940264; PubMed Central PMCID: PMC1914868.
van der Luijt RB, Meera Khan P, Vasen HF, Breukel C, Tops CM, Scott RJ, Fodde R. Germline mutations in the 3′ part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli. Hum Genet. 1996 Dec;98(6):727-34. PubMed PMID: 8931709.
Vasen HF, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G, Nagengast FM, Meijers-Heijboer EH, Bertario L, Varesco L, Bisgaard ML, Mohr J, Fodde R, Khan PM. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology. 1996 Apr;110(4):1020-7. Erratum in: Gastroenterology 1996 Nov;111(5):1402. PubMed PMID: 8612988.
Wijnen J, Khan PM, Vasen H, Menko F, van der Klift H, van den Broek M, van Leeuwen-Cornelisse I, Nagengast F, Meijers-Heijboer EJ, Lindhout D, Griffioen G, Cats A, Kleibeuker J, Varesco L, Bertario L, Bisgaard ML, Mohr J, Kolodner R, Fodde R. Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16. Am J Hum Genet. 1996 Feb;58(2):300-7. PubMed PMID: 8571956; PubMed Central PMCID: PMC1914526.
van der Luijt RB, Vasen HF, Tops CM, Breukel C, Fodde R, Meera Khan P. APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis. Hum Genet. 1995 Dec;96(6):705-10. PubMed PMID: 8522331.
Fodde R, Khan PM. Genotype-phenotype correlations at the adenomatous polyposis coli (APC) gene. Crit Rev Oncog. 1995;6(3-6):291-303. Review. PubMed PMID: 9012588.
Wijnen J, Fodde R, Khan PM. DGGE polymorphism in intron 10 of MSH2, the HNPCC gene. Hum Mol Genet. 1994 Dec;3(12):2268. PubMed PMID: 7881445.
Fodde R, Edelmann W, Yang K, van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM, et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8969-73. PubMed PMID: 8090754; PubMed Central PMCID: PMC44728.
Brahe C, Velonà I, van der Steege G, Zappata S, van de Veen AY, Osinga J, Tops CM, Fodde R, Khan PM, Buys CH, et al. Mapping of two new markers within the smallest interval harboring the spinal muscular atrophy locus by family and radiation hybrid analysis. Hum Genet. 1994 May;93(5):494-501. PubMed PMID: 8168823.
van der Luijt R, Khan PM, Vasen H, van Leeuwen C, Tops C, Roest P, den Dunnen J, Fodde R. Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test. Genomics. 1994 Mar 1;20(1):1-4. PubMed PMID: 8020934.
Fodde R, Losekoot M. Mutation detection by denaturing gradient gel electrophoresis (DGGE). Hum Mutat. 1994;3(2):83-94. Review. PubMed PMID: 8199599.
van den Broek MH, Jhanwar SC, Fodde R, Chaganti RS, Meera Khan PM. p53 mutations in colorectal cancers in the patients of Metropolitan New York. Anticancer Res. 1993 Sep-Oct;13(5C):1769-72. PubMed PMID: 8267380.
Renault B, van den Broek M, Fodde R, Wijnen J, Pellegata NS, Amadori D, Khan PM, Ranzani GN. Base transitions are the most frequent genetic changes at P53 in gastric cancer. Cancer Res. 1993 Jun 1;53(11):2614-7. PubMed PMID: 8495424.
Velonà I, Zappata S, Tops CM, Fodde R, Khan PM, Neri G, Brahe C. Dinucleotide repeat polymorphism proximal to the spinal muscular atrophy region at the D5S524 locus. Hum Mol Genet. 1993 Jun;2(6):829. PubMed PMID: 8353514.
Van Den Broek MH, Renault B, Fodde R, Verspaget H, Griffioen G, Khan PM. Sites and types of p53 mutations in an unselected series of colorectal cancers in The Netherlands. Anticancer Res. 1993 May-Jun;13(3):587-92. PubMed PMID: 8317886.
Kielman MF, Smits R, Devi TS, Fodde R, Bernini LF. Homology of a 130-kb region enclosing the alpha-globin gene cluster, the alpha-locus controlling region, and two non-globin genes in human and mouse. Mamm Genome. 1993;4(6):314-23. PubMed PMID: 8318735.
Wallis Y, MacDonald F, Rindl PM, Hulten M, McKeown C, Morton DG, Keighley MR, Fodde R, van der Luijt R, Khan PM. Germline APC mutation familial adenomatous polyposis in Indian family. Lancet. 1992 Oct 24;340(8826):1035. PubMed PMID: 1357420.
Pellegata NS, Losekoot M, Fodde R, Pugliese V, Saccomanno S, Renault B, Bernini LF, Ranzani GN. Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer. Anticancer Res. 1992 Sep-Oct;12(5):1731-5. PubMed PMID: 1444240.
Losekoot M, van Heeren H, Schipper JJ, Giordano PC, Bernini LF, Fodde R. Rapid detection of the highly polymorphic beta globin framework by denaturing gradient gel electrophoresis. J Med Genet. 1992 Aug;29(8):574-7. PubMed PMID: 1355561; PubMed Central PMCID: PMC1016066.
Fodde R, van der Luijt R, Wijnen J, Tops C, van der Klift H, van Leeuwen-Cornelisse I, Griffioen G, Vasen H, Khan PM. Eight novel inactivating germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis. Genomics. 1992 Aug;13(4):1162-8. PubMed PMID: 1324223.
Losekoot M, Fodde R, Giordano PC. [Hemoglobinopathies, screening and molecular-genetic studies in foreign women in The Netherlands]. Ned Tijdschr Geneeskd. 1992 Jul 25;136(30):1477-8. Dutch. PubMed PMID: 1369781.
Tops CM, Vasen HF, van Berge Henegouwen G, Simoons PP, van de Klift HM, van Leeuwen SJ, Breukel C, Fodde R, den Hartog Jager FC, Nagengast FM, et al. Genetic evidence that Turcot syndrome is not allelic to familial adenomatous polyposis. Am J Med Genet. 1992 Jul 15;43(5):888-93. PubMed PMID: 1322639.
Gottardi E, Losekoot M, Fodde R, Saglio G, Camaschella C, Bernini LF. Rapid identification by denaturing gradient gel electrophoresis of mutations in the gamma-globin gene promoters in non-deletion type HPFH. Br J Haematol. 1992 Apr;80(4):533-8. PubMed PMID: 1374633.
Wijnen J, Tops C, Breukel C, van Leeuwen C, Goverde A, van der Klift H, Fodde R, Khan PM. CA repeat polymorphism from YAC JW25 at the D5S318 locus, distal to adenomatous polyposis coli (APC). Nucleic Acids Res. 1991 Dec 25;19(24):6965. PubMed PMID: 1662372; PubMed Central PMCID: PMC329349.
Breukel C, Tops C, van Leeuwen C, van der Klift H, Fodde R, Khan PM. AT repeat polymorphism at the D5S122 locus tightly linked to adenomatous polyposis coli (APC). Nucleic Acids Res. 1991 Dec 11;19(23):6665. PubMed PMID: 1661411; PubMed Central PMCID: PMC329275.
van Leeuwen C, Tops C, Breukel C, van der Klift H, Deaven L, Fodde R, Khan PM. CA repeat polymorphism within the MCC (mutated in colorectal cancer) gene. Nucleic Acids Res. 1991 Oct 25;19(20):5805. PubMed PMID: 1945868; PubMed Central PMCID: PMC329021.
Breukel C, Tops C, van Leeuwen C, van der Klift H, Nakamura Y, Fodde R, Khan PM. CA repeat polymorphism at the D5S82 locus, proximal to adenomatous polyposis coli (APC). Nucleic Acids Res. 1991 Oct 25;19(20):5804. PubMed PMID: 1945867; PubMed Central PMCID: PMC329019.
van Leeuwen C, Tops C, Breukel C, van der Klift H, Fodde R, Khan PM. CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC). Nucleic Acids Res. 1991 Oct 25;19(20):5805. PubMed PMID: 1658745; PubMed Central PMCID: PMC329022.
Losekoot M, Fodde R, Harteveld CL, van Heeren H, Giordano PC, Went LN, Bernini LF. Homozygous beta+ thalassaemia owing to a mutation in the cleavage-polyadenylation sequence of the human beta globin gene. J Med Genet. 1991 Apr;28(4):252-5. PubMed PMID: 1856830; PubMed Central PMCID: PMC1016827.
Losekoot M, Fodde R, Gerritsen EJ, van de Kuit I, Schreuder A, Giordano PC, Vossen JM, Bernini LF. Interaction of two different disorders in the beta-globin gene cluster associated with an increased hemoglobin F production: a novel deletion type of (G) gamma + ((A) gamma delta beta)(0)-thalassemia and a delta(0)-hereditary persistence of fetal hemoglobin determinant. Blood. 1991 Feb 15;77(4):861-7. PubMed PMID: 1704267.
Fodde R, Harteveld CL, Losekoot M, Giordano PC, Khan PM, Nayudu NV, Bernini LF. Multiple recombination events are responsible for the heterogeneity of alpha(+)-thalassemia haplotypes among the forest tribes of Andhra Pradesh, India. Ann Hum Genet. 1991 Jan;55(Pt 1):43-50. PubMed PMID: 2042935.
Fodde R, Losekoot M, Casula L, Bernini LF. Nucleotide sequence of the Belgian G gamma+(A gamma delta beta)0-thalassemia deletion breakpoint suggests a common mechanism for a number of such recombination events. Genomics. 1990 Dec;8(4):732-5. PubMed PMID: 2276746.
Losekoot M, Fodde R, Harteveld CL, van Heeren H, Giordano PC, Bernini LF. Denaturing gradient gel electrophoresis and direct sequencing of PCR amplified genomic DNA: a rapid and reliable diagnostic approach to beta thalassaemia. Br J Haematol. 1990 Oct;76(2):269-74. PubMed PMID: 2094329.
Fodde R, Harteveld CL, van Heeren H, Losekoot M, Bernini LF. A new AvaII RFLP in the human alpha-globin gene cluster. Nucleic Acids Res. 1990 May 25;18(10):3104. PubMed PMID: 1971926; PubMed Central PMCID: PMC330888.
Saris JJ, Breuning MH, Dauwerse HG, Snijdewint FG, Top B, Fodde R, van Ommen GJ. Rapid detection of polymorphism near gene for adult polycystic kidney disease. Lancet. 1990 May 5;335(8697):1102-3. PubMed PMID: 1970405.
Losekoot M, Fodde R, van Heeren H, Harteveld CL, Giordano PC, Bernini LF. A novel frameshift mutation [FSC 47 (+A)] causing beta-thalassemia in a Surinam patient. Hemoglobin. 1990;14(4):467-70. PubMed PMID: 2283303.
Giordano PC, Fodde R, Amons R, Ploem JE, Bernini LF. Hb J-Anatolia [alpha 61(E10)Lys—-Thr]: structural characterization and gene localization of a new alpha chain variant. Hemoglobin. 1990;14(2):119-28. PubMed PMID: 2272835.
Losekoot M, Fodde R, Giordano PC, Bernini LF. A novel delta zero-thalassemia arising from a frameshift insertion, detected by direct sequencing of enzymatically amplified DNA. Hum Genet. 1989 Aug;83(1):75-8. PubMed PMID: 2767680.
Fodde R, Losekoot M, van den Broek MH, Oldenburg M, Rashida N, Schreuder A, Wijnen JT, Giordano PC, Nayudu NV, Khan PM, et al. Prevalence and molecular heterogeneity of alfa+ thalassemia in two tribal populations from Andhra Pradesh, India. Hum Genet. 1988 Oct;80(2):157-60. PubMed PMID: 3169739.