Lab Publications


Strating E, Verhagen MP, Wensink E, Dünnebach E, Wijler L, Aranguren I, De la Cruz AS, Peters NA, Hageman JH, van der Net MMC, van Schelven S, Laoukili J, Fodde R, Roodhart J, Nierkens S, Snippert H, Gloerich M, Rinkes IB, Elias SG, Kranenburg O. Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer. Front Immunol (2023) 14:1053920. doi: 10.3389/fimmu.2023.1053920.

Verhagen M, Joosten R, Schmitt M, Sacchetti A, Choi J, Välimäki N, Aaltonen L, Augenlicht L. Fodde R. Paneth cells as the origin of intestinal cancer in the context of inflammation. Research Square [Preprint; currently under review] (2023). doi: 10.21203/

Stabile, R., Cabezas, M.R., Verhagen, M.P. Tucci, F.A., van den Bosch, T.P.P., De Herdt, M.J., van der Steen, B., Nigg, A.L., Chen, M., Ivan, C., Shimizu, M., Koljenović, S., Hardillo, J.A., Verrijzer, C.P., Baatenburg de Jong, R.J., Calin, G.A., Fodde R. The deleted in oral cancer (DOC1 aka CDK2AP1) tumor suppressor gene is downregulated in oral squamous cell carcinoma by multiple microRNAs. Cell Death Dis (2023) 14:337-350.


Xu T, Verhagen M, Joosten R, Sun W, Sacchetti A, Munoz Sagredo L, Orian-Rousseau V, Fodde R. Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer. eLife (2022); 11:e82006. doi: 10.7554/eLife.82006.

Strating E, Wassenaar E, Verhagen M, Rauwerdink P, van Schelven S, de Hingh I, Rinkes IB, Boerma D, Witkamp A, Lacle M, Fodde R, Volckmann R, Koster J, Stedingk K, Giesel F, de Roos R, Poot A, Bol G, Lam M, Elias S, Kranenburg O. Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by 68/Ga-FAPI-PET imaging. Br J Cancer (2022) 127(1):145-155. doi: 10.1038/s41416-022-01748-z.


Sacchetti A, Teeuwssen M, Verhagen M, Joosten R, Xu T, Stabile R, van der Steen B, Watson MM, Gusinac A, Kim WK, Ubink I, Van de Werken HJ, Fumagalli A, Paauwe M, Van Rheenen J, Sansom OJ, Kranenburg O, Fodde R. Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. eLife (2021);10:e61461 DOI: 10.7554/eLife.61461


Atlasi Y, van Dorsten RT, Sacchetti A, Joosten R, Oosterhuis JW, Looijenga LHJ, Fodde R. Ectopic activation of WNT signaling in human embryonal carcinoma cells and its effects in short- and long-term in vitro culture. Sci Rep (2019) 9:11928  | PDF

Teeuwssen M, and Fodde R. Cell Heterogeneity and Phenotypic Plasticity in Metastasis Formation: The Case of Colon Cancer. Cancers (2019), 11(9), 1368; PDF

Teeuwssen M, and Fodde R  Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance, J Clin Med (2019), 8(10), 1658. PDF

Wang T, Song P, Zhong T, Wang X, Xiang X, Liu Q, Chen H, Xia T, Liu H, Niu Y, Hu Y, Xu L, Shao Y, Zhu L, Qi H, Shen J, Hou T, Fodde R & Shao J. The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties. Oncogene 38:4932–4947 (2019)


Schmitt M, Schewe M, Sacchetti A, Feijtel D, van de Geer WS, Teeuwssen M, Sleddens HF, Joosten R, van Royen ME, van de Werken HJG, van Es J, Clevers H, Fodde R. Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling. Cell Reports 2018 Aug 28;24(9):2312-2328.e7. doi: 10.1016/j.celrep.2018.07.085. PDF­ reports/abstract/S2211­1247(18)31203­8

Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R., Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Research. 2018 Apr;28(4):432-447. doi: 10.1101/gr.225128.117. PDF

Schewe M, Fodde R. Multitasking Paneth Cells in the Intestinal Stem Cell Niche. From: Advances in Stem Cells and their Niches (Chapter 2), Edited by Dominique Bonnet. ISSN: 2468-5097, Vol: 2, Page: 41-75 (2018). Elsevier BV. PDF


Schewe M, Sacchetti A, Schmitt M, Fodde R. The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells. J Vis Exp. 2017 Nov 20;(129). PDF VIDEO

Mohd-Sarip A, Teeuwssen M, Bot AG, De Herdt MJ, Willems SM, Baatenburg de Jong RJ, Looijenga LHJ, Zatreanu D, Bezstarosti K, van Riet J, Oole E, van Ijcken WFJ, van de Werken HJG, Demmers JA, Fodde R, Verrijzer CP. DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells. Cell Rep. 2017 Jul 5;20(1):61-75. PDF

Fodde R, Schmitt M, Schewe M, Augenlicht LH. Modelling western dietary habits in the mouse: easier said than done. Hepatobiliary Surg Nutr. 2017 Apr;6(2):138-140. PDF

Rodríguez-Colman MJ, Schewe M, Meerlo M, Stigter E, Gerrits J, Pras-Raves M, Sacchetti A, Hornsveld M, Oost KC, Snippert HJ, Verhoeven-Duif N, Fodde R, Burgering BM. Interplay between metabolic identities in the intestinal crypt supports stem cell function. Nature. 2017 Mar 16;543(7645):424-427.  PDF


Atlasi Y, Noori R, Marolin I, Franken P, Brandao J, Biermann K, Collini P, Grigorian M, Lukanidin E, Ambartsumian N, and Riccardo Fodde. The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression. European Journal of Cancer 68 (2016) 114-124.

Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R. Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer. Cell Stem Cell. 2016 Jul 7;19(1):38-51. doi: 10.1016/j.stem.2016.05.023. Epub 2016 Jun 9. PubMed PMID: 27292189.

Famili F, Brugman MH, Taskesen E, Naber BE, Fodde R, Staal FJ. High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells. Stem Cell Reports. 2016 May 10;6(5):652-9. doi: 10.1016/j.stemcr.2016.04.009. PubMed PMID: 27167156; PubMed Central PMCID: PMC4939829. PDF

Cremers N, Neeb A, Uhle T, Dimmler A, Rothley M, Allgayer H, Fodde R, Sleeman JP, Thiele W. CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models. PLoS One. 2016 Mar 15;11(3):e0151468. doi: 10.1371/journal.pone.0151468. eCollection 2016. PubMed PMID: 26978528; PubMed Central PMCID: PMC4792398. PDF


Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Møller P, Viel A, Genuardi M, Fodde R, Bellacosa A. Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis. Oncotarget. 2015 Dec 15;6(40):42892-904. doi: 10.18632/oncotarget.5740. PubMed PMID: 26503472; PubMed Central PMCID: PMC4767479. PDF

van der Zee M, Sacchetti A, Cansoy M, Joosten R, Teeuwssen M, Heijmans-Antonissen C, Ewing-Graham PC, Burger CW, Blok LJ, Fodde R. IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+Stem-like Component and Reduces Tumor Burden. Cancer Res. 2015 Sep 1;75(17):3608-22. doi: 10.1158/0008-5472.CAN-14-2498. Epub 2015 Jun 30. PubMed PMID: 26130650. PDF

Ling H, Vincent K, Pichler M, Fodde R, Berindan-Neagoe I, Slack FJ, Calin GA. Junk DNA and the long non-coding RNA twist in cancer genetics. Oncogene. 2015 Sep 24;34(39):5003-11. doi: 10.1038/onc.2014.456. Epub 2015 Jan 26. Review. PubMed PMID: 25619839; PubMed Central PMCID: PMC4552604.


Reimers MS, Bastiaannet E, Langley RE, van Eijk R, van Vlierberghe RL, Lemmens VE, van Herk-Sukel MP, van Wezel T, Fodde R, Kuppen PJ, Morreau H, van de Velde CJ, Liefers GJ. Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer. JAMA Intern Med. 2014 May;174(5):732-9. doi: 10.1001/jamainternmed.2014.511. PubMed PMID: 24687028.

Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T. Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia. Mol Brain. 2014 Mar 29;7:21. doi: 10.1186/1756-6606-7-21. PubMed PMID: 24678719; PubMed Central PMCID: PMC3986642. PDF

Atlasi Y, Looijenga L, Fodde R. Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective. Curr Top Dev Biol. 2014;107:373-404. doi: 10.1016/B978-0-12-416022-4.00013-5. Review. PubMed PMID: 24439813.


Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, Zhang X, de Weerd V, Shimizu M, Ling H, Buiga R, Pop V, Irimie A, Fodde R, Bedrosian I, Martens JW, Foekens JA, Berindan-Neagoe I, Calin GA. CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget. 2013 Oct;4(10):1748-62. PubMed PMID: 24077681; PubMed Central PMCID: PMC3858561. PDF

Ghazvini M, Sonneveld P, Kremer A, Franken P, Sacchetti A, Atlasi Y, Roth S, Joosten R, Smits R, Fodde R. Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis. PLoS One. 2013 Sep 17;8(9):e73872. doi: 10.1371/journal.pone.0073872. eCollection 2013. PubMed PMID: 24069241; PubMed Central PMCID: PMC3775784. PDF

Monteiro J, Gaspar C, Richer W, Franken PF, Sacchetti A, Joosten R, Idali A, Brandao J, Decraene C, Fodde R. Cancer stemness in Wnt-driven mammary tumorigenesis. Carcinogenesis. 2014 Jan;35(1):2-13. doi: 10.1093/carcin/bgt279. Epub 2013 Aug 16. PubMed PMID: 23955540. PDF

Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep;23(9):1446-61. doi: 10.1101/gr.152942.112. Epub 2013 Jun 24. PubMed PMID: 23796952; PubMed Central PMCID: PMC3759721. PDF

Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R. Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation. PLoS Genet. 2013 May;9(5):e1003424. doi: 10.1371/journal.pgen.1003424. Epub 2013 May 2. PubMed PMID: 23658527; PubMed Central PMCID: PMC3642041. PDF

van der Zee M, Jia Y, Wang Y, Heijmans-Antonissen C, Ewing PC, Franken P, DeMayo FJ, Lydon JP, Burger CW, Fodde R, Blok LJ. Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J Pathol. 2013 May;230(1):48-58. doi: 10.1002/path.4160. Epub 2013 Mar 14. PubMed PMID: 23288720. PDF


Mathers JC, Movahedi M, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans G, Maher ER, Bertario L, Bisgaard ML, Dunlop M, Ho JW, Hodgson S, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen H, Gerdes AM, Barker G, Crawford G, Elliott F, Pylvanainen K, Wijnen J, Fodde R, Lynch H, Bishop DT, Burn J; CAPP2 Investigators. Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol. 2012 Dec;13(12):1242-9. doi: 10.1016/S1470-2045(12)70475-8. Epub 2012 Nov 7. PubMed PMID: 23140761.

Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Fodde R, Itoh M, Senda T. Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc. Med Mol Morphol. 2012 Jun;45(3):161-7. Epub 2012 Sep 22. PubMed PMID: 23001298.

Wang Y, Sacchetti A, van Dijk MR, van der Zee M, van der Horst PH, Joosten R, Burger CW, Grootegoed JA, Blok LJ, Fodde R. Identification of quiescent, stem-like cells in the distal female reproductive tract. PLoS One. 2012;7(7):e40691. doi: 10.1371/journal.pone.0040691. Epub 2012 Jul 24. PubMed PMID: 22848396; PubMed Central PMCID: PMC3404087.

Sampieri K, Fodde R. Cancer stem cells and metastasis. Semin Cancer Biol. 2012 Jun;22(3):187-93. Review. PubMed PMID: 22774232.

Roth S, Franken P, Sacchetti A, Kremer A, Anderson K, Sansom O, Fodde R. Paneth cells in intestinal homeostasis and tissue injury. PLoS One. 2012;7(6):e38965. doi: 10.1371/journal.pone.0038965. Epub 2012 Jun 20. PubMed PMID: 22745693; PubMed Central PMCID: PMC3380033.

Roth S, Franken P, Monkhorst K, Kong a San J, Fodde R. Generation and characterization of an inducible transgenic model for studying mouse esophageal biology. BMC Dev Biol. 2012 Jun 12;12:18. doi: 10.1186/1471-213X-12-18. PubMed PMID: 22690876; PubMed Central PMCID: PMC3483200.

Bastiaannet E, Sampieri K, Dekkers OM, de Craen AJ, van Herk-Sukel MP, Lemmens V, van den Broek CB, Coebergh JW, Herings RM, van de Velde CJ, Fodde R, Liefers GJ. Use of aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer. 2012 Apr 24;106(9):1564-70. doi: 10.1038/bjc.2012.101. Epub 2012 Mar 27. PubMed PMID: 22454078; PubMed Central PMCID: PMC3341868.

Sleeman JP, Christofori G, Fodde R, Collard JG, Berx G, Decraene C, Rüegg C. Concepts of metastasis in flux: the stromal progression model. Semin Cancer Biol. 2012 Jun;22(3):174-86. doi: 10.1016/j.semcancer.2012.02.007. Epub 2012 Feb 21. Review. PubMed PMID: 22374376.

Fijneman RJ, de Wit M, Pourghiasian M, Piersma SR, Pham TV, Warmoes MO, Lavaei M, Piso C, Smit F, Delis-van Diemen PM, van Turenhout ST, Terhaar sive Droste JS, Mulder CJ, Blankenstein MA, Robanus-Maandag EC, Smits R, Fodde R, van Hinsbergh VW, Meijer GA, Jimenez CR. Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer. Clin Cancer Res. 2012 May 1;18(9):2613-24. doi: 10.1158/1078-0432.CCR-11-1937. Epub 2012 Feb 20. PubMed PMID: 22351690.


Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Oda N, Fodde R, Itoh M, Senda T. The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function. Med Mol Morphol. 2011 Dec;44(4):207-12. doi: 10.1007/s00795-010-0529-9. Epub 2011 Dec 17. PubMed PMID: 22179183.

Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans DG, Maher ER, Bertario L, Bisgaard ML, Dunlop MG, Ho JW, Hodgson SV, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen HF, Barker G, Crawford G, Elliott F, Movahedi M, Pylvanainen K, Wijnen JT, Fodde R, Lynch HT, Mathers JC, Bishop DT; CAPP2 Investigators. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet. 2011 Dec 17;378(9809):2081-7. doi: 10.1016/S0140-6736(11)61049-0. Epub 2011 Oct 27. PubMed PMID: 22036019; PubMed Central PMCID: PMC3243929.

Luis TC, Naber BA, Roozen PP, Brugman MH, de Haas EF, Ghazvini M, Fibbe WE, van Dongen JJ, Fodde R, Staal FJ. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell. 2011 Oct 4;9(4):345-56. doi: 10.1016/j.stem.2011.07.017. PubMed PMID: 21982234.

Robanus-Maandag E, Bosch C, Amini-Nik S, Knijnenburg J, Szuhai K, Cervera P, Poon R, Eccles D, Radice P, Giovannini M, Alman BA, Tejpar S, Devilee P, Fodde R. Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids. PLoS One. 2011;6(9):e24354. doi: 10.1371/journal.pone.0024354. Epub 2011 Sep 9. PubMed PMID: 21931686; PubMed Central PMCID: PMC3170296.

Roth S, Fodde R. Quiescent stem cells in intestinal homeostasis and cancer. Cell Commun Adhes. 2011 Jun;18(3):33-44. doi: 10.3109/15419061.2011.615422. Epub 2011 Sep 14. PubMed PMID: 21913875.

Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schüller U. Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors. Mol Cell Biol. 2011 Aug;31(16):3326-38. doi: 10.1128/MCB.05718-11. Epub 2011 Jun 20. PubMed PMID: 21690300; PubMed Central PMCID: PMC3147790.

Wang Y, Jia Y, Franken P, Smits R, Ewing PC, Lydon JP, DeMayo FJ, Burger CW, Anton Grootegoed J, Fodde R, Blok LJ. Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice. Mol Cell Endocrinol. 2011 Jul 20;341(1-2):48-54. doi: 10.1016/j.mce.2011.05.026. Epub 2011 Jun 1. PubMed PMID: 21664244.

Roth S, Fodde R. The nature of intestinal stem cells’ nurture. EMBO Rep. 2011 Jun;12(6):483-4. doi: 10.1038/embor.2011.97. Epub 2011 May 13. PubMed PMID: 21566649; PubMed Central PMCID: PMC3128296.

Burn J, Bishop DT, Chapman PD, Elliott F, Bertario L, Dunlop MG, Eccles D, Ellis A, Evans DG, Fodde R, Maher ER, Möslein G, Vasen HF, Coaker J, Phillips RK, Bülow S, Mathers JC; International CAPP consortium. A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. Cancer Prev Res (Phila). 2011 May;4(5):655-65. doi: 10.1158/1940-6207.CAPR-11-0106. PubMed PMID: 21543343; PubMed Central PMCID: PMC3092423.

van Veelen W, Le NH, Helvensteijn W, Blonden L, Theeuwes M, Bakker ER, Franken PF, van Gurp L, Meijlink F, van der Valk MA, Kuipers EJ, Fodde R, Smits R. β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis. Gut. 2011 Sep;60(9):1204-12. doi: 10.1136/gut.2010.233460. Epub 2011 Feb 9. PubMed PMID: 21307168; PubMed Central PMCID: PMC3152867.

Grotenhuis BA, Franken PF, Swinkels WJ, Boonstra A, van der Valk MA, van Lanschot JJ, Fodde R. Early morbidity encountered in the dietary-related mouse model of Barrett’s esophagus: a question of zinc? Dis Esophagus. 2011 Jul;24(5):371-3. doi: 10.1111/j.1442-2050.2010.01151.x. Epub 2010 Dec 17. PubMed PMID: 21166735.

Meunier D, Patra K, Smits R, Hägebarth A, Lüttges A, Jaussi R, Wieduwilt MJ, Quintanilla-Fend L, Himmelbauer H, Fodde R, Fundele RH. Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors. Mol Carcinog. 2011 Jan;50(1):8-15. doi: 10.1002/mc.20692. PubMed PMID: 21061267.


Wang Y, van der Zee M, Fodde R, Blok LJ. Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer. Oncotarget. 2010 Nov;1(7):674-84. Review. PubMed PMID: 21317462; PubMed Central PMCID: PMC3248134.

Out AA, Tops CM, Nielsen M, Weiss MM, van Minderhout IJ, Fokkema IF, Buisine MP, Claes K, Colas C, Fodde R, Fostira F, Franken PF, Gaustadnes M, Heinimann K, Hodgson SV, Hogervorst FB, Holinski-Feder E, Lagerstedt-Robinson K, Olschwang S, van den Ouweland AM, Redeker EJ, Scott RJ, Vankeirsbilck B, Grønlund RV, Wijnen JT, Wikman FP, Aretz S, Sampson JR, Devilee P, den Dunnen JT, Hes FJ. Leiden Open Variation Database of the MUTYH gene. Hum Mutat. 2010 Nov;31(11):1205-15. doi: 10.1002/humu.21343. PubMed PMID: 20725929.

Grotenhuis BA, Dinjens WN, Wijnhoven BP, Sonneveld P, Sacchetti A, Franken PF, van Dekken H, Tilanus HW, van Lanschot JJ, Fodde R. Barrett’s oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers. J Pathol. 2010 Aug;221(4):379-89. doi: 10.1002/path.2733. PubMed PMID: 20549647.

Albuquerque C, Baltazar C, Filipe B, Penha F, Pereira T, Smits R, Cravo M, Lage P, Fidalgo P, Claro I, Rodrigues P, Veiga I, Ramos JS, Fonseca I, Leitão CN, Fodde R. Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability. Genes Chromosomes Cancer. 2010 Aug;49(8):746-59. doi: 10.1002/gcc.20786. PubMed PMID: 20544848.

Fodde R, Tomlinson I. Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma. J Pathol. 2010 Jul;221(3):239-41. doi: 10.1002/path.2718. PubMed PMID: 20527017.

Monteiro J, Fodde R. Cancer stemness and metastasis: therapeutic consequences and perspectives. Eur J Cancer. 2010 May;46(7):1198-203. doi: 10.1016/j.ejca.2010.02.030. Epub 2010 Mar 18. Review. PubMed PMID: 20303259.

Robanus-Maandag EC, Koelink PJ, Breukel C, Salvatori DC, Jagmohan-Changur SC, Bosch CA, Verspaget HW, Devilee P, Fodde R, Smits R. A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis. 2010 May;31(5):946-52. doi: 10.1093/carcin/bgq046. Epub 2010 Feb 22. PubMed PMID: 20176656.


Wang Y, Hanifi-Moghaddam P, Hanekamp EE, Kloosterboer HJ, Franken P, Veldscholte J, van Doorn HC, Ewing PC, Kim JJ, Grootegoed JA, Burger CW, Fodde R, Blok LJ. Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer. Clin Cancer Res. 2009 Sep 15;15(18):5784-93. doi: 10.1158/1078-0432.CCR-09-0814. Epub 2009 Sep 8. PubMed PMID: 19737954.

Gaspar C, Franken P, Molenaar L, Breukel C, van der Valk M, Smits R, Fodde R. A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. PLoS Genet. 2009 Jul;5(7):e1000547. doi: 10.1371/journal.pgen.1000547. Epub 2009 Jul 3. PubMed PMID: 19578404; PubMed Central PMCID: PMC2697381.

Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC. Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009 Apr 8;9:26. doi: 10.1186/1471-213X-9-26. PubMed PMID: 19356224; PubMed Central PMCID: PMC2678105.

Fodde R. The stem of cancer. Cancer Cell. 2009 Feb 3;15(2):87-9. doi: 10.1016/j.ccr.2009.01.011. PubMed PMID: 19185843.

Roth S, Franken P, van Veelen W, Blonden L, Raghoebir L, Beverloo B, van Drunen E, Kuipers EJ, Rottier R, Fodde R, Smits R. Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology. Genesis. 2009 Jan;47(1):7-13. doi: 10.1002/dvg.20446. PubMed PMID: 18942097.


Burn J, Bishop DT, Mecklin JP, Macrae F, Möslein G, Olschwang S, Bisgaard ML, Ramesar R, Eccles D, Maher ER, Bertario L, Jarvinen HJ, Lindblom A, Evans DG, Lubinski J, Morrison PJ, Ho JW, Vasen HF, Side L, Thomas HJ, Scott RJ, Dunlop M, Barker G, Elliott F, Jass JR, Fodde R, Lynch HT, Mathers JC; CAPP2 Investigators. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med. 2008 Dec 11;359(24):2567-78. doi: 10.1056/NEJMoa0801297. Erratum in: N Engl J Med. 2009 Apr 2;360(14):1470. PubMed PMID: 19073976.

Alberici P, Gaspar C, Franken P, Gorski MM, de Vries I, Scott RJ, Ristimäki A, Aaltonen LA, Fodde R. Smad4 haploinsufficiency: a matter of dosage. Pathogenetics. 2008 Nov 3;1(1):2. doi: 10.1186/1755-8417-1-2. PubMed PMID: 19014666; PubMed Central PMCID: PMC2580039.

Liljegren A, Barker G, Elliott F, Bertario L, Bisgaard ML, Eccles D, Evans G, Macrae F, Maher E, Lindblom A, Rotstein S, Nilsson B, Mecklin JP, Möslein G, Jass J, Fodde R, Mathers J, Burn J, Bishop DT. Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol. 2008 Jul 10;26(20):3434-9. doi: 10.1200/JCO.2007.13.2795. PubMed PMID: 18612159; PubMed Central PMCID: PMC2645083.

Le NH, Franken P, Fodde R. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br J Cancer. 2008 Jun 17;98(12):1886-93. doi: 10.1038/sj.bjc.6604401. Epub 2008 May 27. Review. PubMed PMID: 18506144; PubMed Central PMCID: PMC2441948.

Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J. cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7281-6. doi: 10.1073/pnas.0711190105. Epub 2008 May 19. PubMed PMID: 18490653; PubMed Central PMCID: PMC2387183.

Gaspar C, Cardoso J, Franken P, Molenaar L, Morreau H, Möslein G, Sampson J, Boer JM, de Menezes RX, Fodde R. Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis. Am J Pathol. 2008 May;172(5):1363-80. doi: 10.2353/ajpath.2008.070851. Epub 2008 Apr 10. PubMed PMID: 18403596; PubMed Central PMCID: PMC2329845.


Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am J Pathol. 2007 Aug;171(2):654-66. Epub 2007 Jun 14. PubMed PMID: 17569777; PubMed Central PMCID: PMC1934515.

van Dekken H, Wink JC, Vissers KJ, Franken PF, Ruud Schouten W, J Hop WC, Kuipers EJ, Fodde R, Janneke van der Woude C. Wnt pathway-related gene expression during malignant progression in ulcerative colitis. Acta Histochem. 2007;109(4):266-72. Epub 2007 Apr 18. PubMed PMID: 17445872.

Fodde R, Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol. 2007 Apr;19(2):150-8. Epub 2007 Feb 16. Review. PubMed PMID: 17306971.

Alberici P, de Pater E, Cardoso J, Bevelander M, Molenaar L, Jonkers J, Fodde R. Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human. Am J Pathol. 2007 Jan;170(1):377-87. PubMed PMID: 17200209; PubMed Central PMCID: PMC1762685.

Cardoso J, Boer J, Morreau H, Fodde R. Expression and genomic profiling of colorectal cancer. Biochim Biophys Acta. 2007 Jan;1775(1):103-37. Epub 2006 Aug 22. Review. PubMed PMID: 17010523.


Alberici P, Fodde R. The role of the APC tumor suppressor in chromosomal instability. Genome Dyn. 2006;1:149-70. doi: 10.1159/000092506. Review. PubMed PMID: 18724059.

Fodde R. Stem cells and metastatic cancer: fatal attraction? PLoS Med. 2006 Dec;3(12):e482. PubMed PMID: 17194186; PubMed Central PMCID: PMC1762040.

Drabek K, van Ham M, Stepanova T, Draegestein K, van Horssen R, Sayas CL, Akhmanova A, Ten Hagen T, Smits R, Fodde R, Grosveld F, Galjart N. Role of CLASP2 in microtubule stabilization and the regulation of persistent motility. Curr Biol. 2006 Nov 21;16(22):2259-64. PubMed PMID: 17113391.

Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, Rosty C, Abal M, El Marjou F, Smits R, Louvard D, Fodde R, Robine S. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology. 2006 Oct;131(4):1096-109. Epub 2006 Aug 16. Erratum in: Gastroenterology. 2006 Dec;131(6):2029. PubMed PMID: 17030180.

Sakai H, Visser R, Ikegawa S, Ito E, Numabe H, Watanabe Y, Mikami H, Kondoh T, Kitoh H, Sugiyama R, Okamoto N, Ogata T, Fodde R, Mizuno S, Takamura K, Egashira M, Sasaki N, Watanabe S, Nishimaki S, Takada F, Nagai T, Okada Y, Aoka Y, Yasuda K, Iwasa M, Kogaki S, Harada N, Mizuguchi T, Matsumoto N. Comprehensive genetic analysis of relevant four genes in 49 patients with Marfan syndrome or Marfan-related phenotypes. Am J Med Genet A. 2006 Aug 15;140(16):1719-25. PubMed PMID: 16835936.

Cardoso J, Molenaar L, de Menezes RX, van Leerdam M, Rosenberg C, Möslein G, Sampson J, Morreau H, Boer JM, Fodde R. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res. 2006 Mar 1;66(5):2514-9. PubMed PMID: 16510566.

Lynch HT, Boland CR, Gong G, Shaw TG, Lynch PM, Fodde R, Lynch JF, de la Chapelle A. Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet. 2006 Apr;14(4):390-402. Review. PubMed PMID: 16479259.

Lynch HT, de la Chapelle A, Hampel H, Wagner A, Fodde R, Lynch JF, Okimoto R, Clark MB, Coronel S, Trowonou A, Fu YX, Haynatzki GR, Gong G. American founder mutation for Lynch syndrome. Prevalence estimates and implications. Cancer. 2006 Jan 15;106(2):448-52. PubMed PMID: 16353207.

Siezen CL, Tijhuis MJ, Kram NR, van Soest EM, de Jong DJ, Fodde R, van Kranen HJ, Kampman E. Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta. Pharmacogenet Genomics. 2006 Jan;16(1):43-50. PubMed PMID: 16344721.

Alberici P, Jagmohan-Changur S, De Pater E, Van Der Valk M, Smits R, Hohenstein P, Fodde R. Smad4 haploinsufficiency in mouse models for intestinal cancer. Oncogene. 2006 Mar 23;25(13):1841-51. PubMed PMID: 16288217.


Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, Vokes EE, Lane WS, Huang CC, Caldes T, Di Cristofano A, Hampel H, Nilsson I, von Heijne G, Fodde R, Murty VV, de la Chapelle A, Weghorst CM. Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA. 2005 Oct 5;294(13):1634-46. PubMed PMID: 16204663.

Nielsen M, Franken PF, Reinards TH, Weiss MM, Wagner A, van der Klift H, Kloosterman S, Houwing-Duistermaat JJ, Aalfs CM, Ausems MG, Bröcker-Vriends AH, Gomez Garcia EB, Hoogerbrugge N, Menko FH, Sijmons RH, Verhoef S, Kuipers EJ, Morreau H, Breuning MH, Tops CM, Wijnen JT, Vasen HF, Fodde R, Hes FJ. Multiplicity in polyp count and extracolonic manifestations in 40 Dutch patients with MYH associated polyposis coli (MAP). J Med Genet. 2005 Sep;42(9):e54. PubMed PMID: 16140997; PubMed Central PMCID: PMC1736132.

van der Klift H, Wijnen J, Wagner A, Verkuilen P, Tops C, Otway R, Kohonen-Corish M, Vasen H, Oliani C, Barana D, Moller P, Delozier-Blanchet C, Hutter P, Foulkes W, Lynch H, Burn J, Möslein G, Fodde R. Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes MSH2, MLH1, MSH6, and PMS2 responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Genes Chromosomes Cancer. 2005 Oct;44(2):123-38. PubMed PMID: 15942939.

Bian Y, Caldes T, Wijnen J, Franken P, Vasen H, Kaklamani V, Nafa K, Peterlongo P, Ellis N, Baron JA, Burn J, Moeslein G, Morrison PJ, Chen Y, Ahsan H, Watson P, Lynch HT, de la Chapelle A, Fodde R, Pasche B. TGFBR1*6A may contribute to hereditary colorectal cancer. J Clin Oncol. 2005 May 1;23(13):3074-8. PubMed PMID: 15860866.

Nagtegaal ID, Gaspar CG, Peltenburg LT, Marijnen CA, Kapiteijn E, van de Velde CJ, Fodde R, van Krieken JH. Radiation induces different changes in expression profiles of normal rectal tissue compared with rectal carcinoma. Virchows Arch. 2005 Feb;446(2):127-35. Epub 2004 Dec 16. PubMed PMID: 15602683.


Cardoso J, Molenaar L, de Menezes RX, Rosenberg C, Morreau H, Möslein G, Fodde R, Boer JM. Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH. Nucleic Acids Res. 2004 Oct 28;32(19):e146. PubMed PMID: 15514107; PubMed Central PMCID: PMC528818.

Nagtegaal I, Gaspar C, Marijnen C, Van De Velde C, Fodde R, Van Krieken H. Morphological changes in tumour type after radiotherapy are accompanied by changes in gene expression profile but not in clinical behaviour. J Pathol. 2004 Oct;204(2):183-92. PubMed PMID: 15378567.

Gaspar C, Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol. 2004;48(5-6):377-86. Review. PubMed PMID: 15349813.

Kong Y, Poon R, Nadesan P, Di Muccio T, Fodde R, Khokha R, Alman BA. Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. Cancer Res. 2004 Aug 15;64(16):5795-803. PubMed PMID: 15313922.

Hendriks YM, Wagner A, Morreau H, Menko F, Stormorken A, Quehenberger F, Sandkuijl L, Møller P, Genuardi M, Van Houwelingen H, Tops C, Van Puijenbroek M, Verkuijlen P, Kenter G, Van Mil A, Meijers-Heijboer H, Tan GB, Breuning MH, Fodde R, Wijnen JT, Bröcker-Vriends AH, Vasen H. Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance. Gastroenterology. 2004 Jul;127(1):17-25. PubMed PMID: 15236168.

de Boer J, Siddappa R, Gaspar C, van Apeldoorn A, Fodde R, van Blitterswijk C. Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells. Bone. 2004 May;34(5):818-26. PubMed PMID: 15121013.

Barana D, van der Klift H, Wijnen J, Longa ED, Radice P, Cetto GL, Fodde R, Oliani C. Spectrum of genetic alterations in Muir-Torre syndrome is the same as in HNPCC. Am J Med Genet A. 2004 Mar 15;125A(3):318-9. PubMed PMID: 14994245.

Lynch HT, Coronel SM, Okimoto R, Hampel H, Sweet K, Lynch JF, Barrows A, Wijnen J, van der Klift H, Franken P, Wagner A, Fodde R, de la Chapelle A. A founder mutation of the MSH2 gene and hereditary nonpolyposis colorectal cancer in the United States. JAMA. 2004 Feb 11;291(6):718-24. PubMed PMID: 14871915.


Tolg C, Poon R, Fodde R, Turley EA, Alman BA. Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene. 2003 Oct 9;22(44):6873-82. PubMed PMID: 14534534.

Bezrookove V, Smits R, Moeslein G, Fodde R, Tanke HJ, Raap AK, Darroudi F. Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers. Genes Chromosomes Cancer. 2003 Oct;38(2):177-86. PubMed PMID: 12939745.

Watson P, Narod SA, Fodde R, Wagner A, Lynch JF, Tinley ST, Snyder CL, Coronel SA, Riley B, Kinarsky Y, Lynch HT. Carrier risk status changes resulting from mutation testing in hereditary non-polyposis colorectal cancer and hereditary breast-ovarian cancer. J Med Genet. 2003 Aug;40(8):591-6. PubMed PMID: 12920070; PubMed Central PMCID: PMC1735553.

Hohenstein P, Fodde R. Of mice and (wo)men: genotype-phenotype correlations in BRCA1. Hum Mol Genet. 2003 Oct 15;12 Spec No 2:R271-7. Epub 2003 Aug 5. Review. Erratum in: Hum Mol Genet. 2004 Feb 15;13(4):473. PubMed PMID: 12915453.

Soravia C, van der Klift H, Bründler MA, Blouin JL, Wijnen J, Hutter P, Fodde R, Delozier-Blanchet C. Prostate cancer is part of the hereditary non-polyposis colorectal cancer (HNPCC) tumor spectrum. Am J Med Genet A. 2003 Aug 30;121A(2):159-62. PubMed PMID: 12910497.

Vrolijk H, Sloos W, Mesker W, Franken P, Fodde R, Morreau H, Tanke H. Automated acquisition of stained tissue microarrays for high-throughput evaluation of molecular targets. J Mol Diagn. 2003 Aug;5(3):160-7. PubMed PMID: 12876206; PubMed Central PMCID: PMC1907332.

Scheenstra R, Rijcken FE, Koornstra JJ, Hollema H, Fodde R, Menko FH, Sijmons RH, Bijleveld CM, Kleibeuker JH. Rapidly progressive adenomatous polyposis in a patient with germline mutations in both the APC and MLH1 genes: the worst of two worlds. Gut. 2003 Jun;52(6):898-9. PubMed PMID: 12740349; PubMed Central PMCID: PMC1773670.

Meijers-Heijboer H, Wijnen J, Vasen H, Wasielewski M, Wagner A, Hollestelle A, Elstrodt F, van den Bos R, de Snoo A, Fat GT, Brekelmans C, Jagmohan S, Franken P, Verkuijlen P, van den Ouweland A, Chapman P, Tops C, Möslein G, Burn J, Lynch H, Klijn J, Fodde R, Schutte M. The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. Am J Hum Genet. 2003 May;72(5):1308-14. Epub 2003 Apr 10. PubMed PMID: 12690581; PubMed Central PMCID: PMC1180284.

Wagner A, Barrows A, Wijnen JT, van der Klift H, Franken PF, Verkuijlen P, Nakagawa H, Geugien M, Jaghmohan-Changur S, Breukel C, Meijers-Heijboer H, Morreau H, van Puijenbroek M, Burn J, Coronel S, Kinarski Y, Okimoto R, Watson P, Lynch JF, de la Chapelle A, Lynch HT, Fodde R. Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder genomic deletion of the MSH2 gene. Am J Hum Genet. 2003 May;72(5):1088-100. Epub 2003 Mar 25. PubMed PMID: 12658575; PubMed Central PMCID: PMC1180263.

Lynch HT, Taylor RJ, Lynch JF, Knezetic JA, Barrows A, Fodde R, Wijnen J, Wagner A. Multiple primary cancer, including transitional cell carcinoma of the upper uroepithelial tract in a multigeneration HNPCC family: molecular genetic, diagnostic, and management implications. Am J Gastroenterol. 2003 Mar;98(3):664-70. PubMed PMID: 12650804.

Fodde R. The multiple functions of tumour suppressors: it’s all in APC. Nat Cell Biol. 2003 Mar;5(3):190-2. PubMed PMID: 12646874.

Hohenstein P, Molenaar L, Elsinga J, Morreau H, van der Klift H, Struijk A, Jagmohan-Changur S, Smits R, van Kranen H, van Ommen GJ, Cornelisse C, Devilee P, Fodde R. Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene. Genes Chromosomes Cancer. 2003 Mar;36(3):273-82. PubMed PMID: 12557227.

Hendriks Y, Franken P, Dierssen JW, De Leeuw W, Wijnen J, Dreef E, Tops C, Breuning M, Bröcker-Vriends A, Vasen H, Fodde R, Morreau H. Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors. Am J Pathol. 2003 Feb;162(2):469-77. PubMed PMID: 12547705; PubMed Central PMCID: PMC1851154.

Jagmohan-Changur S, Poikonen T, Vilkki S, Launonen V, Wikman F, Orntoft TF, Møller P, Vasen H, Tops C, Kolodner RD, Mecklin JP, Järvinen H, Bevan S, Houlston RS, Aaltonen LA, Fodde R, Wijnen J, Karhu A. EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. Cancer Res. 2003 Jan 1;63(1):154-8. PubMed PMID: 12517792.


Kielman MF, Rindapää M, Gaspar C, van Poppel N, Breukel C, van Leeuwen S, Taketo MM, Roberts S, Smits R, Fodde R. Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet. 2002 Dec;32(4):594-605. Epub 2002 Nov 11. Erratum in: Nat Genet. 2003 Jan;33(1):107.. PubMed PMID: 12426568.

Fodde R, Smits R. Cancer biology. A matter of dosage. Science. 2002 Oct 25;298(5594):761-3. PubMed PMID: 12399571.

Wagner A, van der Klift H, Franken P, Wijnen J, Breukel C, Bezrookove V, Smits R, Kinarsky Y, Barrows A, Franklin B, Lynch J, Lynch H, Fodde R. A 10-Mb paracentric inversion of chromosome arm 2p inactivates MSH2 and is responsible for hereditary nonpolyposis colorectal cancer in a North-American kindred. Genes Chromosomes Cancer. 2002 Sep;35(1):49-57. PubMed PMID: 12203789.

Albuquerque C, Breukel C, van der Luijt R, Fidalgo P, Lage P, Slors FJ, Leitão CN, Fodde R, Smits R. The ‘just-right’ signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet. 2002 Jun 15;11(13):1549-60. PubMed PMID: 12045208.

Fodde R. The APC gene in colorectal cancer. Eur J Cancer. 2002 May;38(7):867-71. Review. PubMed PMID: 11978510.


Fodde R, Smits R, Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer. 2001 Oct;1(1):55-67. Review. PubMed PMID: 11900252.

Stormorken AT, Müller W, Lemkemeyer B, Apold J, Wijnen JT, Fodde R, Möslein G, Møller P. Prediction of the outcome of genetic testing in HNPCC kindreds using the revised Amsterdam criteria and immunohistochemistry. Fam Cancer. 2001;1(3-4):169-73. PubMed PMID: 14574174.

Ridanpää M, Fodde R, Kielman M. Dynamic expression and nuclear accumulation of beta-catenin during the development of hair follicle-derived structures. Mech Dev. 2001 Dec;109(2):173-81. PubMed PMID: 11731231.

Stella A, Wagner A, Shito K, Lipkin SM, Watson P, Guanti G, Lynch HT, Fodde R, Liu B. A nonsense mutation in MLH1 causes exon skipping in three unrelated HNPCC families. Cancer Res. 2001 Oct 1;61(19):7020-4. PubMed PMID: 11585727.

Fodde R, Smits R. Disease model: familial adenomatous polyposis. Trends Mol Med. 2001 Aug;7(8):369-73. Review. PubMed PMID: 11516998.

Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R. A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50. PubMed PMID: 11420664.

Wagner A, Hendriks Y, Meijers-Heijboer EJ, de Leeuw WJ, Morreau H, Hofstra R, Tops C, Bik E, Bröcker-Vriends AH, van Der Meer C, Lindhout D, Vasen HF, Breuning MH, Cornelisse CJ, van Krimpen C, Niermeijer MF, Zwinderman AH, Wijnen J, Fodde R. Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree. J Med Genet. 2001 May;38(5):318-22. PubMed PMID: 11333868; PubMed Central PMCID: PMC1734864.

Poon R, Smits R, Li C, Jagmohan-Changur S, Kong M, Cheon S, Yu C, Fodde R, Alman BA. Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). Oncogene. 2001 Jan 25;20(4):451-60. PubMed PMID: 11313976.

Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, Clevers H. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol. 2001 Apr;3(4):433-8. PubMed PMID: 11283620.


Peelen T, de Leeuw W, van Lent K, Morreau H, van Eijk R, van Vliet M, Wijnen J, Ligtenberg M, Ginjaar HB, Zweemer R, Menko F, Fodde R, van Ommen GJ, Vasen HF, Cornelisse CJ, Devilee P. Genetic analysis of a breast-ovarian cancer family, with 7 cases of colorectal cancer linked to BRCA1, fails to support a role for BRCA1 in colorectal tumorigenesis. Int J Cancer. 2000 Dec 1;88(5):778-82. PubMed PMID: 11072248.

Sijmons R, Hofstra R, Hollema H, Mensink R, van der Hout A, Hoekstra H, Kleibeuker J, Molenaar W, Wijnen J, Fodde R, Vasen H, Buys C. Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer. Genes Chromosomes Cancer. 2000 Dec;29(4):353-5. PubMed PMID: 11066081.

Bouffler SD, Hofland N, Cox R, Fodde R. Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis. Br J Cancer. 2000 Nov;83(10):1291-4. PubMed PMID: 11044352; PubMed Central PMCID: PMC2408782.

Smits R, Ruiz P, Diaz-Cano S, Luz A, Jagmohan-Changur S, Breukel C, Birchmeier C, Birchmeier W, Fodde R. E-cadherin and adenomatous polyposis coli mutations are synergistic in intestinal tumor initiation in mice. Gastroenterology. 2000 Oct;119(4):1045-53. PubMed PMID: 11040191.

Smits R, Hofland N, Edelmann W, Geugien M, Jagmohan-Changur S, Albuquerque C, Breukel C, Kucherlapati R, Kielman MF, Fodde R. Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity. Genes Chromosomes Cancer. 2000 Nov;29(3):229-39. PubMed PMID: 10992298.

Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B. A germline mutation at the extreme 3′ end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor. Clin Genet. 2000 Mar;57(3):205-12. PubMed PMID: 10782927.

Fidalgo P, Almeida MR, West S, Gaspar C, Maia L, Wijnen J, Albuquerque C, Curtis A, Cravo M, Fodde R, Leitao CN, Burn J. Detection of mutations in mismatch repair genes in Portuguese families with hereditary non-polyposis colorectal cancer (HNPCC) by a multi-method approach. Eur J Hum Genet. 2000 Jan;8(1):49-53. PubMed PMID: 10713887.

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